| Gene: | TLR1 |
| GeneID: | ENSG00000174125 |
| Chrom: | 4 |
| Start position: | 38790677 |
| End position: | 38856817 |
| Pathway: | Toll-like receptor signaling pathway |
| Class: | Organismal Systems; Immune system |
| FST gene level: | 0.0905249 |
| Number of nsSNPs: | 6 |
| nsSNPs in gene: | rs4833095 rs5743611 rs5743612 rs5743618 rs76600635 rs76796448 |
| Gene Structure: |  |
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Overall distribution |
Tissue specific distribution |
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Overall distribution |
Tissue specific distribution |
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Overall distribution |
Tissue specific distribution |
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| Functional class: | Not specified |
| JensenLab PubMed score: | 374.70 (Percentile rank: 88.44%) |
| PubTator score: | 204.75 (Percentile rank: 86.14%) |
| Target development/druggability level: | TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code. |
| Tractability (small molecule): | Predicted TractableTargets with a predicted Ro5 druggable domain (druggable genome); Targets with a drugEBIlity score equal or greater than 0 |
| Tractability (antibody): | Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted |
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Data portal developer
Yuxin Wang MD, PhD
University of Pennsylvania School of Medicine
Peking Union Medical College Hospital