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      Gene:  SPHK1
      GeneID:  ENSG00000176170
      Chrom:  17
      Start position:  76376584
      End position:  76387860
      Pathway:  Fc gamma R-mediated phagocytosis
      Class:  Organismal Systems; Immune system
      FST gene level:  0.0874793
      Number of nsSNPs:  2
      nsSNPs in gene:  rs2247856
rs346803
      Gene Structure:  

    

    
  Overall distribution
    
  Tissue specific distribution
    
 
  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
      Functional class:  Kinase
      JensenLab PubMed score:  583.62  (Percentile rank: 91.98%)
      PubTator score:  400.59  (Percentile rank: 91.90%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    

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Data portal developer
Yuxin Wang MD, PhD
University of Pennsylvania School of Medicine
Peking Union Medical College Hospital