| Gene: | NOTCH3 |
| GeneID: | ENSG00000074181 |
| Chrom: | 19 |
| Start position: | 15159038 |
| End position: | 15200995 |
| Pathway: | Th1 and Th2 cell differentiation |
| Class: | Organismal Systems; Immune system |
| FST gene level: | 0.0953167 |
| Number of nsSNPs: | 4 |
| nsSNPs in gene: | rs10408676 rs1044009 rs114447350 rs35769976 |
| Gene Structure: |  |
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Overall distribution |
Tissue specific distribution |
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Overall distribution |
Tissue specific distribution |
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Overall distribution |
Tissue specific distribution |
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| Functional class: | Not specified |
| JensenLab PubMed score: | 458.36 (Percentile rank: 90.23%) |
| PubTator score: | 721.71 (Percentile rank: 95.28%) |
| Target development/druggability level: | TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below. |
| Tractability (small molecule): | Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands |
| Tractability (antibody): | Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets |
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Data portal developer
Yuxin Wang MD, PhD
University of Pennsylvania School of Medicine
Peking Union Medical College Hospital