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Description of image       
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      Gene:  NOTCH1
      GeneID:  ENSG00000148400
      Chrom:  9
      Start position:  136494433
      End position:  136546048
      Pathway:  Th1 and Th2 cell differentiation
      Class:  Organismal Systems; Immune system
      FST gene level:  0.122969
      Number of nsSNPs:  1
      nsSNPs in gene:  rs61751489
      Gene Structure:  

    

    
  Overall distribution
    
  Tissue specific distribution
    
 
  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.23  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.90  (Driver)
 
Recurrently mutated in 2 cancer type(s)
   

    
      Functional class:  Not specified
      JensenLab PubMed score:  11843.16  (Percentile rank: 99.77%)
      PubTator score:  1380.97  (Percentile rank: 97.48%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
      Tractability (antibody):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets

    

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Data portal developer
Yuxin Wang MD, PhD
University of Pennsylvania School of Medicine
Peking Union Medical College Hospital