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Description of image       
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      Gene:  LEPR
      GeneID:  ENSG00000116678
      Chrom:  1
      Start position:  65420652
      End position:  65641559
      Pathway:  Cytokine-cytokine receptor interaction
      Class:  Environmental Information Processing; Signaling molecules and interaction
      FST gene level:  0.170335
      Number of nsSNPs:  2
      nsSNPs in gene:  rs1137100
rs1137101
      Gene Structure:  

    

    
  Overall distribution
    
  Tissue specific distribution
    
 
  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.12  (Driver)
 
Recurrently mutated in 1 cancer type(s)
   

    
      Functional class:  Not specified
      JensenLab PubMed score:  782.63  (Percentile rank: 94.01%)
      PubTator score:  736.45  (Percentile rank: 95.37%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    

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Data portal developer
Yuxin Wang MD, PhD
University of Pennsylvania School of Medicine
Peking Union Medical College Hospital