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      Gene:  KLKB1
      GeneID:  ENSG00000164344
      Chrom:  4
      Start position:  186226438
      End position:  186258471
      Pathway:  Complement and coagulation cascades
      Class:  Organismal Systems; Immune system
      FST gene level:  0.0566563
      Number of nsSNPs:  2
      nsSNPs in gene:  rs3733402
rs4253379
      Gene Structure:  

    

    
  Overall distribution
    
  Tissue specific distribution
    
 
  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
      Functional class:  Enzyme
      JensenLab PubMed score:  720.11  (Percentile rank: 93.39%)
      PubTator score:  111.16  (Percentile rank: 79.13%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
      Tractability (antibody):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets

    

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Data portal developer
Yuxin Wang MD, PhD
University of Pennsylvania School of Medicine
Peking Union Medical College Hospital