| Gene: | CASP4 |
| GeneID: | ENSG00000196954 |
| Chrom: | 11 |
| Start position: | 104942866 |
| End position: | 104969366 |
| Pathway: | Neutrophil extracellular trap formation |
| Class: | Organismal Systems; Immune system |
| FST gene level: | 0.0889944 |
| Number of nsSNPs: | 2 |
| nsSNPs in gene: | rs55901059
rs56226603 |
| Gene Structure: |  |
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| Gscore (Amp): | 0.13 | | Gscore (Del): | 0.33 |
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| Recurrently amplified in 1 cancer type(s) | | Recurrently deleted in 1 cancer type(s) |
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| Recurrently mutated in 1 cancer type(s) |
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| Functional class: | Enzyme |
| JensenLab PubMed score: | 147.33 (Percentile rank: 77.94%) |
| PubTator score: | 143.11 (Percentile rank: 82.25%) |
| Target development/druggability level: | TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below. |
| Tractability (small molecule): | Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets |
| Tractability (antibody): | Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted |
