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      Gene:  ALOX5
      GeneID:  ENSG00000012779
      Chrom:  10
      Start position:  45374176
      End position:  45446119
      Pathway:  Fc epsilon RI signaling pathway
      Class:  Organismal Systems; Immune system
      FST gene level:  0.0554823
      Number of nsSNPs:  1
      nsSNPs in gene:  rs2228065
      Gene Structure:  

    

    
  Overall distribution
    
  Tissue specific distribution
    
 
  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  0.00  
Gscore (Del):  0.00  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
      Functional class:  Enzyme
      JensenLab PubMed score:  1408.88  (Percentile rank: 96.88%)
      PubTator score:  1830.01  (Percentile rank: 98.12%)
      Target development/druggability level:  TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted

    

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Data portal developer
Yuxin Wang MD, PhD
University of Pennsylvania School of Medicine
Peking Union Medical College Hospital