Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SEMG1 | ENSG00000124233 | 1.11 | 1.02 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 2.06 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 1.32 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 3.55 | 1.36 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLPI | ENSG00000124107 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| NPEPL1 | ENSG00000215440 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.00 | 2.70 | 1.66 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 1.25 |
| COL9A3 | ENSG00000092758 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 1.69 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| BIRC7 | ENSG00000101197 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 1.13 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SRMS | ENSG00000125508 | 1.11 | 1.27 | 0.21 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 1.32 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CRYZL1 | ENSG00000205758 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CBR3 | ENSG00000159231 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| DYRK1A | ENSG00000157540 | 0.00 | 1.27 | 0.93 | 1.46 | 0.00 | 0.65 | 2.70 | 1.66 | 0.00 | 1.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 1.67 | 1.32 | 2.15 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 1.42 | 1.90 | 0.00 | 0.00 | 0.00 | 5.10 | 0.00 | 0.00 |
| RIPK4 | ENSG00000183421 | 0.00 | 4.07 | 0.21 | 0.36 | 0.00 | 0.32 | 2.70 | 1.10 | 1.03 | 2.19 | 0.00 | 0.54 | 1.42 | 0.74 | 1.37 | 0.00 | 0.56 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| EMID1 | ENSG00000186998 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.27 | 2.08 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TCN2 | ENSG00000185339 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.19 | 1.72 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 0.81 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| DUSP18 | ENSG00000167065 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TIMP3 | ENSG00000100234 | 1.11 | 0.00 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| MAPK11 | ENSG00000185386 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CAPN7 | ENSG00000131375 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.65 | 5.41 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.81 | 1.39 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| OXSR1 | ENSG00000172939 | 0.00 | 0.25 | 0.10 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KLHL40 | ENSG00000157119 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 1.32 | 1.50 | 0.00 | 1.23 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 1.36 | 0.00 | 0.41 | 0.00 | 1.33 | 0.00 | 0.00 |
| CLEC3B | ENSG00000163815 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| PARP3 | ENSG00000041880 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 1.29 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.94 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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