Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CRLF2 | ENSG00000205755 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PKD2L2 | ENSG00000078795 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 1.39 | 1.13 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| CD164L2 | ENSG00000174950 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| MELK | ENSG00000165304 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.56 | 0.00 | 0.00 | 0.98 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| FIBCD1 | ENSG00000130720 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.13 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| FCN1 | ENSG00000085265 | 0.00 | 1.02 | 0.62 | 0.00 | 0.00 | 1.29 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 1.11 | 0.56 | 1.50 | 0.00 | 0.25 | 0.57 | 0.56 | 0.41 | 0.78 | 0.00 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| ARSE | ENSG00000157399 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 1.61 | 0.00 | 0.00 | 1.29 | 0.60 | 0.00 | 0.27 | 1.07 | 0.74 | 0.39 | 0.00 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| COL26A1 | ENSG00000160963 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 1.08 | 0.36 | 0.74 | 0.00 | 0.28 | 0.94 | 2.15 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| FGF6 | ENSG00000111241 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 0.94 | 1.50 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| OR8G1 | ENSG00000197849 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.28 | 1.32 | 1.93 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| NLGN4Y | ENSG00000165246 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 1.94 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 1.32 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.79 | 0.54 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| PDPK1 | ENSG00000140992 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.00 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PSKH1 | ENSG00000159792 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PLA2G15 | ENSG00000103066 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.56 | 0.19 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| GAA | ENSG00000171298 | 0.00 | 1.27 | 0.00 | 1.09 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 1.88 | 0.64 | 1.23 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| WNT10A | ENSG00000135925 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.00 | 1.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| IHH | ENSG00000163501 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.59 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| NISCH | ENSG00000010322 | 0.00 | 2.29 | 0.00 | 1.09 | 2.86 | 0.32 | 2.70 | 0.00 | 0.77 | 1.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.56 | 1.13 | 2.36 | 1.23 | 1.96 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 1.63 | 2.08 | 0.20 | 0.83 | 2.88 | 0.00 | 0.00 |
| PRKCD | ENSG00000163932 | 0.00 | 1.27 | 0.21 | 0.00 | 2.86 | 0.00 | 2.70 | 0.00 | 1.03 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.25 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SEPP1 | ENSG00000250722 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.54 | 1.07 | 0.00 | 0.00 | 1.11 | 0.75 | 1.50 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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