Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| TEX13A | ENSG00000268629 | 0.00 | 0.00 | 0 | 0 |
| ADGRE4P | ENSG00000268758 | 0.00 | 0.00 | 0 | 0 |
| MMP28 | ENSG00000271447 | 0.00 | 0.00 | 0 | 0 |
| CCL5 | ENSG00000271503 | 0.00 | 0.00 | 0 | 0 |
| KMT2B | ENSG00000272333 | 0.00 | 0.00 | 0 | 0 |
| SERPINA3 | ENSG00000273259 | 0.00 | 0.00 | 0 | 0 |
| OR4M2 | ENSG00000274102 | 0.00 | 0.00 | 0 | 0 |
| GGTLC3 | ENSG00000274252 | 0.00 | 0.00 | 0 | 0 |
| HIST1H3B | ENSG00000274267 | 0.00 | 0.00 | 0 | 0 |
| ADRA2B | ENSG00000274286 | 0.00 | 0.00 | 0 | 0 |
| TPTE | ENSG00000274391 | 0.00 | 0.00 | 0 | 0 |
| HIST1H4F | ENSG00000274618 | 0.00 | 0.00 | 0 | 0 |
| CCL23 | ENSG00000274736 | 0.00 | 0.00 | 0 | 0 |
| HIST1H3E | ENSG00000274750 | 0.00 | 0.00 | 0 | 0 |
| HIST1H4L | ENSG00000275126 | 0.00 | 0.00 | 0 | 0 |
| CCL16 | ENSG00000275152 | 0.00 | 0.00 | 0 | 0 |
| CCL4 | ENSG00000275302 | 0.00 | 0.00 | 0 | 0 |
| HIST1H3I | ENSG00000275379 | 0.00 | 0.00 | 0 | 0 |
| CCL18 | ENSG00000275385 | 0.00 | 0.00 | 0 | 0 |
| FCGBP | ENSG00000275395 | 0.00 | 0.00 | 0 | 0 |
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