Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Overall distribution
Tissue specific distribution
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Overall distribution
Tissue specific distribution
Gscore (Amp):
Gscore (Del):
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Overall distribution
Tissue specific distribution
Mscore:
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Overall
Tissue specific
Total fusion occurrence:
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Overall
Tissue specific
Functional class:
Not specified
JensenLab PubMed score:
NA (Percentile rank: NA)
PubTator score:
NA (Percentile rank: NA)
Target development/druggability level:
Tractability (small molecule):
Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
Tractability (antibody):
Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted
