The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Overall distribution
Tissue specific distribution
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Overall distribution
Tissue specific distribution
Gscore (Amp):
Gscore (Del):
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Overall distribution
Tissue specific distribution
Mscore:
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Overall
Tissue specific
Total fusion occurrence:
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Overall
Tissue specific
Functional class:
Not specified
JensenLab PubMed score:
NA (Percentile rank: NA)
PubTator score:
NA (Percentile rank: NA)
Target development/druggability level:
Tractability (small molecule):
Predicted TractableTargets with a predicted Ro5 druggable domain (druggable genome); Targets with a drugEBIlity score equal or greater than 0
Tractability (antibody):
Predicted Tractable - High confidenceTargets located in the plasma membrane; Targets with GO cell component terms plasma membrane or secreted
