Mutation
The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Overall_Mscore | No. of Cancer Types |
| inositol 1,4,5-trisphosphate receptor type 1 | ENSG00000150995 | ITPR1 | chr3:4493348-4847840:+ | 0.03 | 1 |
| neurotrophic receptor tyrosine kinase 1 | ENSG00000198400 | NTRK1 | chr1:156815640-156881850:+ | 0.03 | 1 |
| toll like receptor 5 | ENSG00000187554 | TLR5 | chr1:223109406-223143282:- | 0.03 | 1 |
| erythrocyte membrane protein band 4.1 like 1 | ENSG00000088367 | EPB41L1 | chr20:36091504-36232799:+ | 0.03 | 1 |
| transferrin receptor | ENSG00000072274 | TFRC | chr3:196027183-196082189:- | 0.03 | 1 |
| solute carrier family 11 member 1 | ENSG00000018280 | SLC11A1 | chr2:218382029-218396894:+ | 0.03 | 1 |
| LIM domain and actin binding 1 | ENSG00000050405 | LIMA1 | chr12:50175788-50283546:- | 0.03 | 1 |
| transmembrane 9 superfamily member 3 | ENSG00000077147 | TM9SF3 | chr10:96518109-96587452:- | 0.03 | 1 |
| CXADR Ig-like cell adhesion molecule | ENSG00000154639 | CXADR | chr21:17512382-17593579:+ | 0.02 | 1 |
| FYN proto-oncogene, Src family tyrosine kinase | ENSG00000010810 | FYN | chr6:111660332-111873452:- | 0.02 | 1 |
| PX domain containing serine/threonine kinase like | ENSG00000168297 | PXK | chr3:58332880-58426126:+ | 0.02 | 1 |
| plasmalemma vesicle associated protein | ENSG00000130300 | PLVAP | chr19:17351448-17377350:- | 0.02 | 1 |
| thioredoxin related transmembrane protein 3 | ENSG00000166479 | TMX3 | chr18:68673688-68715298:- | 0.02 | 1 |
| plexin D1 | ENSG00000004399 | PLXND1 | chr3:129555175-129606818:- | 0.02 | 1 |
| integrin subunit beta 4 | ENSG00000132470 | ITGB4 | chr17:75721328-75757818:+ | 0.02 | 1 |
| membrane palmitoylated protein 5 | ENSG00000072415 | MPP5 | chr14:67241109-67335819:+ | 0.02 | 1 |
| syndecan binding protein | ENSG00000137575 | SDCBP | chr8:58552924-58582860:+ | 0.02 | 1 |
| T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | ENSG00000110719 | TCIRG1 | chr11:68039016-68050895:+ | 0.02 | 1 |
| phosphatidylinositol 4-kinase alpha | ENSG00000241973 | PI4KA | chr22:20707691-20859417:- | 0.02 | 1 |
| junctophilin 1 | ENSG00000104369 | JPH1 | chr8:74234700-74321328:- | 0.02 | 1 |
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