Mutation

 

The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Pan-cancer level overall M-score of GESPs


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 HGNC Name  Ensembl Gene ID  HGNC Symbol  Genomic Location  Overall_Mscore  No. of Cancer Types 
catenin beta 1ENSG00000168036CTNNB1chr3:41194837-41260096:+  3.55    10  
epidermal growth factor receptorENSG00000146648EGFRchr7:55019021-55256620:+  2.15    4  
G protein subunit alpha qENSG00000156052GNAQchr9:77716087-78031458:-  1.5    1  
FAT atypical cadherin 1ENSG00000083857FAT1chr4:186587783-186726722:-  1.31    2  
notch receptor 1ENSG00000148400NOTCH1chr9:136494444-136545862:-  0.9    2  
erb-b2 receptor tyrosine kinase 2ENSG00000141736ERBB2chr17:39687914-39730426:+  0.85    6  
beta-2-microglobulinENSG00000166710B2Mchr15:44711477-44718877:+  0.79    3  
ankyrin 3ENSG00000151150ANK3chr10:60026298-60733490:-  0.74    2  
KIT proto-oncogene, receptor tyrosine kinaseENSG00000157404KITchr4:54657918-54740715:+  0.66    2  
fibroblast growth factor receptor 3ENSG00000068078FGFR3chr4:1793307-1808872:+  0.63    3  
cadherin 1ENSG00000039068CDH1chr16:68737225-68835548:+  0.63    2  
erb-b2 receptor tyrosine kinase 3ENSG00000065361ERBB3chr12:56079857-56103505:+  0.6    3  
ring finger protein 43ENSG00000108375RNF43chr17:58352500-58417595:-  0.58    3  
neurofibromin 2ENSG00000186575NF2chr22:29603556-29698598:+  0.53    3  
ras homolog family member AENSG00000067560RHOAchr3:49359145-49412998:-  0.51    3  
microtubule actin crosslinking factor 1ENSG00000127603MACF1chr1:39081316-39487177:+  0.51    3  
fibroblast growth factor receptor 2ENSG00000066468FGFR2chr10:121478334-121598458:-  0.42    3  
activin A receptor type 2AENSG00000121989ACVR2Achr2:147844517-147930826:+  0.4    4  
EPH receptor A5ENSG00000145242EPHA5chr4:65319563-65670495:-  0.39    2  
APC membrane recruitment protein 1ENSG00000184675AMER1chrX:64185117-64205744:-  0.34    1  

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