Mutation
The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Overall_Mscore | No. of Cancer Types |
| anoctamin 6 | ENSG00000177119 | ANO6 | chr12:45215987-45440404:+ | 0.04 | 1 |
| leukocyte associated immunoglobulin like receptor 1 | ENSG00000167613 | LAIR1 | chr19:54351384-54370558:- | 0.04 | 1 |
| protein tyrosine phosphatase receptor type F | ENSG00000142949 | PTPRF | chr1:43525187-43623666:+ | 0.04 | 1 |
| integrin subunit beta 3 | ENSG00000259207 | ITGB3 | chr17:47253846-47311816:+ | 0.04 | 1 |
| TNF receptor superfamily member 1A | ENSG00000067182 | TNFRSF1A | chr12:6328757-6342114:- | 0.04 | 1 |
| immunoglobulin superfamily member 3 | ENSG00000143061 | IGSF3 | chr1:116574399-116667755:- | 0.04 | 1 |
| LIM domain containing preferred translocation partner in lipoma | ENSG00000145012 | LPP | chr3:188153284-188890671:+ | 0.04 | 1 |
| tumor suppressor candidate 3 | ENSG00000104723 | TUSC3 | chr8:15417215-15766649:+ | 0.03 | 1 |
| myotubularin 1 | ENSG00000171100 | MTM1 | chrX:150568619-150673322:+ | 0.03 | 1 |
| xenotropic and polytropic retrovirus receptor 1 | ENSG00000143324 | XPR1 | chr1:180632004-180890251:+ | 0.03 | 1 |
| regulator of G protein signaling 1 | ENSG00000090104 | RGS1 | chr1:192575727-192580031:+ | 0.03 | 1 |
| serine peptidase inhibitor, Kunitz type 1 | ENSG00000166145 | SPINT1 | chr15:40844018-40858207:+ | 0.03 | 1 |
| ATPase secretory pathway Ca2+ transporting 2 | ENSG00000064270 | ATP2C2 | chr16:84368527-84464187:+ | 0.03 | 1 |
| membrane metalloendopeptidase | ENSG00000196549 | MME | chr3:155024124-155183729:+ | 0.03 | 1 |
| phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | ENSG00000076641 | PAG1 | chr8:80967810-81112068:- | 0.03 | 1 |
| integrin subunit beta 6 | ENSG00000115221 | ITGB6 | chr2:160099666-160271888:- | 0.03 | 1 |
| ATP binding cassette subfamily C member 3 | ENSG00000108846 | ABCC3 | chr17:50634777-50692252:+ | 0.03 | 1 |
| protein kinase C alpha | ENSG00000154229 | PRKCA | chr17:66302636-66810743:+ | 0.03 | 1 |
| solute carrier family 4 member 7 | ENSG00000033867 | SLC4A7 | chr3:27372721-27484420:- | 0.03 | 1 |
| alkaline phosphatase, placental | ENSG00000163283 | ALPP | chr2:232378534-232382889:+ | 0.03 | 1 |
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