Mutation
The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Overall_Mscore | No. of Cancer Types |
| heat shock protein 90 alpha family class B member 1 | ENSG00000096384 | HSP90AB1 | chr6:44246166-44253888:+ | 0.08 | 3 |
| LDL receptor related protein 12 | ENSG00000147650 | LRP12 | chr8:104489231-104589024:- | 0.08 | 1 |
| amphiphysin | ENSG00000078053 | AMPH | chr7:38383704-38631567:- | 0.08 | 1 |
| integrin subunit alpha X | ENSG00000140678 | ITGAX | chr16:31355134-31382997:+ | 0.08 | 1 |
| tetratricopeptide repeat domain 7B | ENSG00000165914 | TTC7B | chr14:90524564-90816479:- | 0.07 | 2 |
| major histocompatibility complex, class I, A | ENSG00000206503 | HLA-A | chr6:29941260-29945884:+ | 0.07 | 1 |
| selectin L | ENSG00000188404 | SELL | chr1:169690667-169711698:- | 0.07 | 2 |
| ret proto-oncogene | ENSG00000165731 | RET | chr10:43077027-43130351:+ | 0.07 | 1 |
| protein tyrosine phosphatase receptor type M | ENSG00000173482 | PTPRM | chr18:7566782-8406861:+ | 0.07 | 1 |
| integrin subunit beta 1 | ENSG00000150093 | ITGB1 | chr10:32900319-33005792:- | 0.07 | 1 |
| tyrosine kinase non receptor 2 | ENSG00000061938 | TNK2 | chr3:195863364-195911945:- | 0.06 | 1 |
| neuropilin 2 | ENSG00000118257 | NRP2 | chr2:205681990-205798133:+ | 0.06 | 1 |
| signal regulatory protein gamma | ENSG00000089012 | SIRPG | chr20:1629152-1657779:- | 0.06 | 1 |
| protein tyrosine phosphatase non-receptor type 13 | ENSG00000163629 | PTPN13 | chr4:86594315-86815171:+ | 0.06 | 1 |
| PATJ crumbs cell polarity complex component | ENSG00000132849 | INADL | chr1:61742477-62163920:+ | 0.06 | 1 |
| integrin linked kinase | ENSG00000166333 | ILK | chr11:6603708-6610874:+ | 0.06 | 1 |
| anosmin 1 | ENSG00000011201 | ANOS1 | chrX:8528874-8732187:- | 0.06 | 1 |
| ATPase phospholipid transporting 8B1 | ENSG00000081923 | ATP8B1 | chr18:57646426-57803101:- | 0.06 | 1 |
| fms related receptor tyrosine kinase 4 | ENSG00000037280 | FLT4 | chr5:180601506-180649624:- | 0.06 | 1 |
| protein tyrosine phosphatase non-receptor type 4 | ENSG00000088179 | PTPN4 | chr2:119759631-119983818:+ | 0.06 | 1 |
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