Mutation
The putative cancer-causing GESPs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | Overall_Mscore | No. of Cancer Types |
| myosin heavy chain 9 | ENSG00000100345 | MYH9 | chr22:36281281-36388018:- | 0.2 | 3 |
| interleukin 7 receptor | ENSG00000168685 | IL7R | chr5:35852695-35879603:+ | 0.19 | 3 |
| spectrin repeat containing nuclear envelope protein 2 | ENSG00000054654 | SYNE2 | chr14:63852983-64226433:+ | 0.18 | 1 |
| activin A receptor type 1 | ENSG00000115170 | ACVR1 | chr2:157736444-157875862:- | 0.18 | 1 |
| integrin subunit alpha 4 | ENSG00000115232 | ITGA4 | chr2:181457202-181536187:+ | 0.18 | 1 |
| shroom family member 2 | ENSG00000146950 | SHROOM2 | chrX:9786456-9949443:+ | 0.16 | 2 |
| GNAS complex locus | ENSG00000087460 | GNAS | chr20:58839718-58911192:+ | 0.16 | 2 |
| catenin delta 1 | ENSG00000198561 | CTNND1 | chr11:57753243-57819546:+ | 0.15 | 1 |
| fms related receptor tyrosine kinase 1 | ENSG00000102755 | FLT1 | chr13:28300344-28495128:- | 0.14 | 1 |
| kinase insert domain receptor | ENSG00000128052 | KDR | chr4:55078477-55125589:- | 0.14 | 1 |
| glutamate metabotropic receptor 1 | ENSG00000152822 | GRM1 | chr6:146027646-146437598:+ | 0.12 | 1 |
| plexin B2 | ENSG00000196576 | PLXNB2 | chr22:50274979-50307627:- | 0.12 | 1 |
| leptin receptor | ENSG00000116678 | LEPR | chr1:65420652-65641559:+ | 0.12 | 1 |
| colony stimulating factor 2 receptor subunit alpha | ENSG00000198223 | CSF2RA | chrX:1268800-1310381:+ | 0.1 | 1 |
| plasminogen | ENSG00000122194 | PLG | chr6:160702238-160753315:+ | 0.09 | 1 |
| CD93 molecule | ENSG00000125810 | CD93 | chr20:23079349-23086340:- | 0.09 | 1 |
| talin 1 | ENSG00000137076 | TLN1 | chr9:35696948-35732395:- | 0.09 | 2 |
| leucine rich repeat containing G protein-coupled receptor 5 | ENSG00000139292 | LGR5 | chr12:71439770-71586310:+ | 0.09 | 1 |
| microtubule affinity regulating kinase 2 | ENSG00000072518 | MARK2 | chr11:63838928-63911019:+ | 0.09 | 2 |
| heat shock protein family A (Hsp70) member 8 | ENSG00000109971 | HSPA8 | chr11:123057489-123063230:- | 0.08 | 2 |
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