Recurrent Alteration

 

Given that they occur statistically more frequently than the background, recurrent genomic alterations are considered to be under strong selective pressure and more likely play causal roles during tumorigenesis (putative therapeutic targets). To estimate the recurrent alterations of HAMPs at a pan-cancer level, we calculated an overall recurrent score via an unweighted numeric sum of the numbers of recurrent events for a given HAMP across all cancer types.

 

Summary of the overall recurrent scores of the HAMPs across common cancer types


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 HGNC Symbol  Ensembl Gene ID  No. of Cancer  Overall Recurrent Score  Contibution_Mut  Contibution_SCNA_Amp  Contibution_SCNA_Del 
KAT6A  ENSG00000083168    6    6    0    6    0  
KAT6B  ENSG00000156650    1    1    0    1    0  
KAT7  ENSG00000136504    3    3    3    0    0  
KAT5  ENSG00000172977    1    1    0    1    0  
KAT8  ENSG00000103510    2    2    1    1    0  
CLOCK  ENSG00000134852    5    5    0    5    0  
HAT1  ENSG00000128708    0    0    0    0    0  
ELP3  ENSG00000134014    3    3    1    0    2  
KAT2A  ENSG00000108773    1    1    0    0    1  
KAT2B  ENSG00000114166    2    2    1    0    1  
TAF1  ENSG00000147133    2    2    2    0    0  
TAF1L  ENSG00000122728    0    0    0    0    0  
ATAT1  ENSG00000137343    1    1    0    1    0  
CREBBP  ENSG00000005339    4    6    4    0    2  
EP300  ENSG00000100393    8    8    7    1    0  
GTF3C4  ENSG00000125484    2    2    0    0    2  
NCOA1  ENSG00000084676    0    0    0    0    0  
NCOA3  ENSG00000124151    1    1    0    1    0  
SP140  ENSG00000079263    3    3    0    0    3  
SP140L  ENSG00000185404    5    6    1    0    5  

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