Mutation

 

The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.

 

Pan-cancer level overall M-score of PDGs


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 HGNC Symbol  Ensembl Gene ID  Overall_Mscore  No. of Cancer Types 
ATMENSG00000149311  1.10    6  
SIK2ENSG00000170145  0.00    0  
SIK3ENSG00000160584  0.00    0  
HSD17B6ENSG00000025423  0.00    0  
TBK1ENSG00000183735  0.07    2  
CITENSG00000122966  0.00    0  
CAMKK2ENSG00000110931  0.00    0  
COL4A2ENSG00000134871  0.00    0  
EDDM3AENSG00000181562  0.00    0  
RNASE7ENSG00000165799  0.00    0  
ALDH6A1ENSG00000119711  0.02    1  
NEK9ENSG00000119638  0.00    0  
HERC1ENSG00000103657  0.08    1  
DAPK2ENSG00000035664  0.00    0  
ADAMTS17ENSG00000140470  0.00    0  
XYLT1ENSG00000103489  0.00    0  
SMG1ENSG00000157106  0.00    0  
SBK1ENSG00000188322  0.00    0  
MYLK3ENSG00000140795  0.00    0  
MMP2ENSG00000087245  0.05    1  

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