HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Location:
15q22.31
Also known as:
p619, p532
Entrez ID:
8925
Ensembl ID:
ENSG00000103657
Summary:
This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
0.00
Overall distribution
Tissue specific distribution
Mscore:
0.08
Recurrently mutated in 1 cancer type(s)
Overall
Tissue specific
Total fusion occurrence:
17 (Driver)
Fusions detected in 9 cancer type(s)
Overall
Tissue specific
Functional class:
Enzyme
JensenLab PubMed score:
5.75 (Percentile rank: 28.49%)
PubTator score:
21.27 (Percentile rank: 53.35%)
Target development/druggability level:
TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
Tractability (small molecule):
Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
