Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| AGBL1 | ENSG00000166748 | 1.11 | 3.05 | 0.93 | 1.09 | 0.00 | 1.29 | 5.41 | 2.76 | 0.00 | 2.39 | 1.54 | 0.27 | 1.07 | 0.74 | 0.78 | 0.28 | 3.01 | 2.79 | 0.00 | 1.47 | 0.57 | 0.00 | 0.20 | 2.34 | 0.43 | 7.11 | 2.44 | 0.00 | 0.20 | 0.00 | 2.66 | 0.00 | 0.00 |
| NR2F2 | ENSG00000185551 | 0.00 | 0.76 | 0.00 | 1.46 | 0.00 | 0.65 | 2.70 | 0.55 | 0.52 | 1.39 | 0.00 | 0.27 | 1.78 | 0.00 | 0.39 | 1.11 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.81 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| PDIA2 | ENSG00000185615 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.75 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CAPN15 | ENSG00000103326 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 1.20 | 0.00 | 0.27 | 1.07 | 0.00 | 0.00 | 1.11 | 0.56 | 1.72 | 1.23 | 0.00 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 1.90 | 0.54 | 0.69 | 0.20 | 0.00 | 1.55 | 1.82 | 0.00 |
| WFIKKN1 | ENSG00000127578 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| METRN | ENSG00000103260 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 1.25 |
| PRSS29P | ENSG00000196364 | |||||||||||||||||||||||||||||||||
| HAGH | ENSG00000063854 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GFER | ENSG00000127554 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PRSS30P | ENSG00000172460 | |||||||||||||||||||||||||||||||||
| IL32 | ENSG00000008517 | 0.00 | 0.25 | 0.00 | 0.00 | 2.86 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| MEFV | ENSG00000103313 | 1.11 | 1.78 | 0.83 | 1.09 | 0.00 | 1.94 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.83 | 2.64 | 2.58 | 0.00 | 1.72 | 2.30 | 0.56 | 0.41 | 1.56 | 0.43 | 5.45 | 1.36 | 0.00 | 0.41 | 0.00 | 1.77 | 0.00 | 0.00 |
| MTRNR2L4 | ENSG00000232196 | |||||||||||||||||||||||||||||||||
| USP7 | ENSG00000187555 | 0.00 | 1.78 | 0.31 | 1.46 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.54 | 0.00 | 1.47 | 0.39 | 0.83 | 2.26 | 2.36 | 1.23 | 2.70 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 3.32 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| PDXDC1 | ENSG00000179889 | 1.11 | 1.27 | 0.62 | 1.46 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.54 | 1.42 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| EEF2K | ENSG00000103319 | 0.00 | 1.78 | 0.41 | 1.46 | 2.86 | 0.32 | 2.70 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.20 | 0.00 | 1.77 | 1.82 | 0.00 |
| SULT1A2 | ENSG00000197165 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SULT1A1 | ENSG00000196502 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| SULT1A3 | ENSG00000261052 | |||||||||||||||||||||||||||||||||
| CTF1 | ENSG00000150281 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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