Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013]
Overall distribution
Tissue specific distribution
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Overall distribution
Tissue specific distribution
Gscore (Amp):
Gscore (Del):
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Overall distribution
Tissue specific distribution
Mscore:
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Overall
Tissue specific
Total fusion occurrence:
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Overall
Tissue specific
Functional class:
Enzyme
JensenLab PubMed score:
8.42 (Percentile rank: 33.94%)
PubTator score:
52.78 (Percentile rank: 68.81%)
Target development/druggability level:
TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
