Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| RP11-371E8.2 | ENSG00000258595 | |||||||||||||||||||||||||||||||||
| SERPINA3 | ENSG00000273259 | |||||||||||||||||||||||||||||||||
| HHIPL1 | ENSG00000182218 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 1.08 | 0.36 | 0.00 | 0.20 | 0.28 | 1.51 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| WARS | ENSG00000140105 | 0.00 | 0.76 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 1.13 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| RAD51 | ENSG00000051180 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ITPKA | ENSG00000137825 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| ADAL | ENSG00000168803 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TRIM69 | ENSG00000185880 | 0.00 | 1.02 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.28 | 1.13 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DUT | ENSG00000128951 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| RORA | ENSG00000069667 | 0.00 | 1.27 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.54 | 1.42 | 0.00 | 0.00 | 0.56 | 0.75 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 1.08 | 0.69 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| MAP2K5 | ENSG00000137764 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.00 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| NR2E3 | ENSG00000278570 | |||||||||||||||||||||||||||||||||
| SENP8 | ENSG00000166192 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MAN2C1 | ENSG00000140400 | 0.00 | 2.04 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 1.36 | 0.36 | 0.74 | 0.20 | 1.39 | 1.32 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 0.71 | 0.27 | 0.69 | 0.20 | 0.00 | 1.55 | 1.82 | 0.00 |
| PTPN9 | ENSG00000169410 | 2.22 | 2.04 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 0.94 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PEAK1 | ENSG00000173517 | 0.00 | 4.07 | 0.72 | 2.55 | 0.00 | 0.32 | 0.00 | 2.76 | 1.03 | 2.39 | 0.00 | 0.54 | 0.71 | 0.74 | 0.59 | 1.39 | 3.01 | 3.86 | 0.00 | 1.23 | 0.57 | 0.00 | 1.02 | 0.00 | 0.00 | 2.84 | 2.17 | 0.00 | 0.20 | 0.00 | 3.55 | 1.82 | 0.00 |
| PSMA4 | ENSG00000041357 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| ALPK3 | ENSG00000136383 | 1.11 | 2.54 | 0.72 | 2.55 | 2.86 | 0.32 | 0.00 | 2.76 | 0.26 | 2.39 | 0.00 | 1.08 | 1.42 | 0.74 | 0.20 | 0.00 | 1.69 | 4.72 | 3.70 | 1.23 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 6.16 | 1.36 | 0.00 | 0.41 | 0.83 | 3.99 | 0.00 | 0.00 |
| PDE8A | ENSG00000073417 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.98 | 1.67 | 0.38 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| KLHL25 | ENSG00000183655 | 0.00 | 0.51 | 0.31 | 0.00 | 2.86 | 0.65 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 1.08 | 0.00 | 0.00 | 0.39 | 0.00 | 0.56 | 1.29 | 1.23 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
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