Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ATM | ENSG00000149311 | 3.33 | 12.47 | 2.27 | 1.82 | 2.86 | 7.42 | 2.70 | 4.97 | 1.80 | 2.59 | 1.54 | 4.07 | 1.78 | 1.47 | 0.59 | 3.33 | 7.72 | 4.08 | 1.23 | 2.21 | 4.02 | 0.00 | 4.07 | 9.38 | 2.59 | 4.74 | 4.34 | 0.69 | 1.22 | 0.00 | 9.98 | 0.00 | 0.00 |
| SIK2 | ENSG00000170145 | 1.11 | 1.02 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.81 | 0.36 | 0.00 | 0.59 | 0.83 | 1.32 | 1.72 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| SIK3 | ENSG00000160584 | 1.11 | 2.04 | 0.62 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 1.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.56 | 2.36 | 1.23 | 1.96 | 0.57 | 0.00 | 0.61 | 0.00 | 0.86 | 1.90 | 1.90 | 0.00 | 0.00 | 0.83 | 2.66 | 0.00 | 1.25 |
| HSD17B6 | ENSG00000025423 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TBK1 | ENSG00000183735 | 1.11 | 1.53 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.28 | 0.38 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.20 | 0.00 | 1.55 | 1.82 | 0.00 |
| CIT | ENSG00000122966 | 0.00 | 5.09 | 1.34 | 1.46 | 0.00 | 0.97 | 2.70 | 1.10 | 1.03 | 2.39 | 0.00 | 0.54 | 0.71 | 1.47 | 0.78 | 1.39 | 2.26 | 3.65 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 3.79 | 1.90 | 0.00 | 0.20 | 0.00 | 4.43 | 0.00 | 0.00 |
| CAMKK2 | ENSG00000110931 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| COL4A2 | ENSG00000134871 | 0.00 | 1.53 | 0.83 | 2.19 | 0.00 | 1.61 | 0.00 | 1.10 | 1.29 | 1.59 | 0.00 | 0.27 | 1.07 | 0.74 | 0.20 | 1.39 | 4.14 | 6.22 | 1.23 | 1.72 | 1.15 | 0.00 | 0.41 | 1.56 | 0.43 | 6.64 | 1.90 | 0.00 | 0.20 | 0.83 | 3.55 | 0.00 | 1.25 |
| EDDM3A | ENSG00000181562 | 0.00 | 0.00 | 0.52 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| RNASE7 | ENSG00000165799 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ALDH6A1 | ENSG00000119711 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 1.03 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.19 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| NEK9 | ENSG00000119638 | 0.00 | 1.27 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 1.39 | 0.38 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.37 | 1.63 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| HERC1 | ENSG00000103657 | 1.11 | 7.12 | 1.55 | 3.28 | 0.00 | 2.26 | 2.70 | 4.97 | 1.29 | 4.18 | 0.00 | 1.90 | 3.20 | 0.74 | 1.37 | 2.78 | 3.95 | 7.30 | 1.23 | 0.74 | 1.15 | 1.12 | 0.41 | 0.78 | 1.29 | 4.74 | 4.07 | 0.69 | 0.41 | 0.83 | 7.10 | 1.82 | 0.00 |
| DAPK2 | ENSG00000035664 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.83 | 0.56 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ADAMTS17 | ENSG00000140470 | 2.22 | 0.76 | 1.03 | 0.73 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 1.00 | 1.54 | 0.00 | 0.71 | 2.21 | 0.00 | 0.28 | 2.64 | 2.36 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.13 | 1.36 | 0.69 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| XYLT1 | ENSG00000103489 | 0.00 | 1.53 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 1.79 | 1.54 | 0.27 | 0.71 | 0.74 | 0.59 | 0.83 | 5.08 | 2.58 | 0.00 | 1.23 | 1.72 | 0.00 | 1.02 | 0.00 | 0.00 | 3.79 | 0.81 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| SMG1 | ENSG00000157106 | 1.11 | 4.33 | 1.65 | 4.74 | 2.86 | 0.97 | 0.00 | 2.76 | 1.03 | 3.19 | 1.54 | 0.54 | 2.49 | 1.47 | 0.39 | 1.39 | 5.08 | 4.94 | 0.00 | 1.72 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 3.55 | 1.90 | 0.00 | 0.20 | 0.00 | 5.76 | 0.00 | 0.00 |
| SBK1 | ENSG00000188322 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 0.94 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| MYLK3 | ENSG00000140795 | 0.00 | 2.29 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 1.10 | 1.03 | 1.00 | 0.00 | 1.08 | 1.07 | 0.00 | 0.59 | 0.28 | 2.07 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 3.13 | 0.43 | 4.74 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| MMP2 | ENSG00000087245 | 0.00 | 2.29 | 0.10 | 0.73 | 0.00 | 0.00 | 5.41 | 1.66 | 0.26 | 1.00 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.56 | 2.64 | 1.72 | 1.23 | 0.49 | 0.00 | 0.56 | 0.00 | 2.34 | 0.00 | 1.18 | 1.08 | 0.00 | 0.20 | 0.00 | 0.89 | 1.82 | 0.00 |
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