Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PEBP1 | ENSG00000089220 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TAOK3 | ENSG00000135090 | 1.11 | 2.04 | 0.83 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.77 | 0.80 | 0.00 | 1.08 | 0.71 | 0.00 | 0.00 | 0.83 | 1.32 | 2.15 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 1.63 | 0.69 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| SMOC1 | ENSG00000198732 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 1.69 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 2.37 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| PTPN21 | ENSG00000070778 | 0.00 | 2.29 | 0.31 | 0.73 | 0.00 | 0.65 | 2.70 | 2.76 | 0.26 | 1.79 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 1.39 | 0.56 | 1.07 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.90 | 1.08 | 0.00 | 0.20 | 0.00 | 3.10 | 0.00 | 1.25 |
| TDP1 | ENSG00000042088 | 1.11 | 1.02 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 1.51 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| IGHV1-2 | ENSG00000211934 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IGHV3-23 | ENSG00000211949 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 0.75 | 1.07 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| IGHV1-46 | ENSG00000211962 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 1.25 |
| MLKL | ENSG00000168404 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.39 | 0.28 | 0.75 | 1.07 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KARS | ENSG00000065427 | 1.11 | 2.04 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 1.03 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 1.93 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PLCG2 | ENSG00000197943 | 0.00 | 1.53 | 0.72 | 1.09 | 0.00 | 2.58 | 2.70 | 0.55 | 2.84 | 1.39 | 0.00 | 0.27 | 0.71 | 0.74 | 1.18 | 1.67 | 2.64 | 2.58 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 1.56 | 0.00 | 3.79 | 1.08 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| TNK1 | ENSG00000174292 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| ALOXE3 | ENSG00000179148 | 0.00 | 1.53 | 0.52 | 0.73 | 0.00 | 0.65 | 2.70 | 0.00 | 0.26 | 0.80 | 0.00 | 0.81 | 0.00 | 0.74 | 0.00 | 0.28 | 1.13 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 2.37 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| MAP2K4 | ENSG00000065559 | 0.00 | 0.76 | 4.03 | 0.00 | 0.00 | 3.55 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.39 | 1.13 | 1.07 | 0.00 | 0.49 | 1.72 | 0.00 | 0.61 | 2.34 | 0.43 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CDK5R1 | ENSG00000176749 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PIP4K2B | ENSG00000276293 | |||||||||||||||||||||||||||||||||
| CACNB1 | ENSG00000067191 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.80 | 1.54 | 0.00 | 1.07 | 0.00 | 0.00 | 0.56 | 0.75 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.00 | 0.86 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| TEX14 | ENSG00000121101 | 0.00 | 3.82 | 1.14 | 1.46 | 2.86 | 1.61 | 0.00 | 2.21 | 0.52 | 1.00 | 1.54 | 0.54 | 1.42 | 0.74 | 0.39 | 1.39 | 3.20 | 3.22 | 0.00 | 1.47 | 0.57 | 0.56 | 0.61 | 3.13 | 0.43 | 4.03 | 1.08 | 0.00 | 0.20 | 0.83 | 1.77 | 0.00 | 0.00 |
| PRKAR1A | ENSG00000108946 | 5.56 | 0.51 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| SERPINB3 | ENSG00000057149 | 0.00 | 0.51 | 0.52 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 1.29 | 0.00 | 1.54 | 0.00 | 0.71 | 0.00 | 0.39 | 1.11 | 3.77 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 6.64 | 0.81 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
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