phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Location:
17q12
Also known as:
PIP5K2B, PIP5KIIB, PIP5KIIbeta
Entrez ID:
8396
Ensembl ID:
ENSG00000276293
Summary:
The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
0.15
Recurrently deleted in 1 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
NA
Overall
Tissue specific
Total fusion occurrence:
8
Fusions detected in 3 cancer type(s)
Overall
Tissue specific
Functional class:
Kinase
JensenLab PubMed score:
7.47 (Percentile rank: 32.23%)
PubTator score:
15.69 (Percentile rank: 47.81%)
Target development/druggability level:
TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tractability (small molecule):
Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
Tractability (antibody):
Predicted Tractable - Medium to low confidenceTargets with GO cell component terms plasma membrane or secreted with low or unknown confidence; Targets with predicted signal peptide and transmembrane domains; GO cell component - medium confidence; Human Protein Atlas - high confidence
