Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CDC42BPB | ENSG00000198752 | 0.00 | 2.04 | 0.72 | 1.46 | 0.00 | 1.29 | 0.00 | 0.55 | 1.03 | 1.39 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.83 | 0.75 | 2.36 | 0.00 | 1.96 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 3.32 | 1.36 | 0.00 | 0.00 | 0.00 | 3.99 | 1.82 | 0.00 |
| IGHD | ENSG00000211898 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.28 | 1.13 | 0.64 | 0.00 | 0.74 | 0.57 | 0.56 | 0.00 | 0.78 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| ANXA2 | ENSG00000182718 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| CSK | ENSG00000103653 | 1.11 | 1.02 | 0.00 | 0.36 | 0.00 | 0.00 | 8.11 | 0.55 | 0.26 | 0.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.54 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MPI | ENSG00000178802 | 0.00 | 1.78 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 1.47 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| INPP5K | ENSG00000132376 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ALOX15 | ENSG00000161905 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.07 | 0.00 | 0.74 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 1.90 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ALDH3A1 | ENSG00000108602 | 0.00 | 1.02 | 0.00 | 0.00 | 2.86 | 0.65 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| NLK | ENSG00000087095 | 0.00 | 1.53 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 1.66 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 2.21 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RDH8 | ENSG00000080511 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 1.03 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.69 | 1.72 | 0.00 | 0.98 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| MAP4K1 | ENSG00000104814 | 0.00 | 1.78 | 0.52 | 1.09 | 0.00 | 0.65 | 2.70 | 0.00 | 0.77 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 1.51 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 1.56 | 0.86 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| APOE | ENSG00000130203 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CASP8 | ENSG00000064012 | 1.11 | 2.29 | 1.76 | 4.01 | 0.00 | 0.97 | 2.70 | 1.66 | 0.00 | 10.36 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 0.56 | 1.93 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 2.17 | 0.00 | 0.00 | 0.00 | 3.55 | 0.00 | 0.00 |
| ATIC | ENSG00000138363 | 0.00 | 0.00 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.54 | 0.36 | 0.74 | 0.00 | 0.28 | 0.94 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 1.18 | 0.00 | 0.69 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| TGM3 | ENSG00000125780 | 0.00 | 2.29 | 0.41 | 0.00 | 0.00 | 0.65 | 2.70 | 0.55 | 1.29 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 1.32 | 3.00 | 1.23 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GGTLC1 | ENSG00000149435 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TGM2 | ENSG00000198959 | 1.11 | 0.51 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 1.03 | 0.80 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 0.94 | 1.50 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| TXK | ENSG00000074966 | 0.00 | 1.78 | 0.21 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.56 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 2.13 | 0.00 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| ADH1B | ENSG00000196616 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.56 | 1.88 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 7.58 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| NPNT | ENSG00000168743 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 1.90 | 0.00 | 0.74 | 0.20 | 0.00 | 1.69 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.03 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
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