Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ADCK5 | ENSG00000173137 | 0.00 | 0.76 | 0.21 | 1.09 | 0.00 | 1.61 | 0.00 | 0.00 | 0.00 | 0.60 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PRKCZ | ENSG00000067606 | 0.00 | 1.02 | 0.21 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.75 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ANGPTL7 | ENSG00000171819 | 1.11 | 0.00 | 0.10 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| PTP4A2 | ENSG00000184007 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC38A3 | ENSG00000188338 | |||||||||||||||||||||||||||||||||
| COL24A1 | ENSG00000171502 | 0.00 | 3.05 | 1.03 | 1.82 | 0.00 | 1.94 | 2.70 | 2.21 | 1.29 | 3.19 | 0.00 | 1.90 | 0.00 | 0.00 | 0.39 | 1.11 | 3.58 | 6.01 | 1.23 | 0.98 | 1.72 | 0.56 | 0.81 | 1.56 | 0.43 | 4.98 | 4.07 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| OBSCN | ENSG00000154358 | 3.33 | 12.72 | 3.62 | 7.30 | 5.71 | 13.55 | 5.41 | 11.05 | 6.70 | 5.98 | 1.54 | 1.36 | 5.34 | 0.00 | 3.33 | 9.17 | 14.31 | 10.30 | 2.47 | 5.64 | 4.02 | 0.56 | 2.85 | 9.38 | 3.45 | 20.14 | 9.49 | 1.39 | 0.20 | 0.83 | 15.74 | 1.82 | 2.50 |
| LYZL1 | ENSG00000120563 | 2.22 | 0.25 | 0.00 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LYZL2 | ENSG00000151033 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.69 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 1.08 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| PLCE1 | ENSG00000138193 | 1.11 | 1.78 | 1.45 | 1.82 | 0.00 | 2.26 | 8.11 | 2.76 | 1.55 | 3.39 | 0.00 | 1.08 | 0.36 | 1.47 | 0.78 | 1.39 | 3.20 | 3.65 | 0.00 | 0.25 | 1.72 | 0.00 | 0.61 | 1.56 | 0.86 | 9.95 | 1.36 | 0.69 | 0.00 | 0.83 | 4.21 | 0.00 | 1.25 |
| HTRA1 | ENSG00000166033 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 1.66 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CAPN1 | ENSG00000014216 | 0.00 | 1.27 | 0.41 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| LTBP3 | ENSG00000168056 | 1.11 | 0.76 | 0.10 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.00 | 0.60 | 0.00 | 0.27 | 1.07 | 0.00 | 0.20 | 1.11 | 1.13 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 2.37 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| FGF4 | ENSG00000075388 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GNRHR2 | ENSG00000211451 | |||||||||||||||||||||||||||||||||
| NPY6R | ENSG00000226306 | |||||||||||||||||||||||||||||||||
| WNT10B | ENSG00000169884 | 0.00 | 0.51 | 0.10 | 0.73 | 2.86 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RNASE1 | ENSG00000129538 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IL25 | ENSG00000166090 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.25 |
| TPSB2 | ENSG00000197253 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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