Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TPP1 | ENSG00000166340 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 1.61 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 1.13 | 0.43 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| HP | ENSG00000257017 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.43 | 0.00 | 0.25 | 0.57 | 0.56 | 0.00 | 1.56 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.83 | 1.11 | 1.82 | 0.00 |
| MPO | ENSG00000005381 | 0.00 | 0.25 | 0.62 | 1.09 | 0.00 | 1.94 | 2.70 | 1.10 | 0.52 | 1.00 | 0.00 | 0.81 | 0.36 | 0.00 | 0.39 | 1.11 | 2.64 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 1.29 | 3.08 | 1.08 | 0.00 | 0.20 | 0.00 | 2.00 | 1.82 | 0.00 |
| LIPG | ENSG00000101670 | 0.00 | 1.27 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 1.13 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| GDF15 | ENSG00000130513 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ABI3BP | ENSG00000154175 | 0.00 | 2.29 | 0.83 | 0.73 | 0.00 | 2.58 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.27 | 1.07 | 0.00 | 0.59 | 0.56 | 2.45 | 3.00 | 1.23 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 4.74 | 1.63 | 0.00 | 0.20 | 0.83 | 2.22 | 0.00 | 0.00 |
| MAN2B2 | ENSG00000013288 | 0.00 | 1.53 | 0.41 | 0.73 | 0.00 | 0.65 | 2.70 | 1.10 | 0.77 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.83 | 0.75 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.61 | 0.78 | 0.43 | 2.13 | 1.08 | 0.69 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| MMRN1 | ENSG00000138722 | 0.00 | 2.04 | 1.03 | 0.73 | 0.00 | 0.32 | 5.41 | 0.55 | 0.52 | 1.79 | 0.00 | 0.81 | 0.00 | 0.00 | 0.39 | 1.67 | 6.40 | 3.65 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 0.78 | 1.29 | 3.79 | 1.90 | 0.00 | 0.20 | 0.83 | 2.44 | 0.00 | 0.00 |
| CTSV | ENSG00000136943 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.94 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LAMC2 | ENSG00000058085 | 0.00 | 1.02 | 0.62 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.77 | 1.20 | 0.00 | 1.63 | 0.36 | 0.00 | 0.39 | 1.67 | 2.07 | 1.50 | 1.23 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 4.98 | 0.81 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| PRELP | ENSG00000188783 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 1.69 | 0.86 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| TLL2 | ENSG00000095587 | 0.00 | 1.78 | 0.31 | 0.73 | 0.00 | 1.29 | 5.41 | 1.10 | 0.77 | 1.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.59 | 0.28 | 3.01 | 2.58 | 1.23 | 0.98 | 1.15 | 0.00 | 0.41 | 0.78 | 0.43 | 4.98 | 0.27 | 0.00 | 0.20 | 0.83 | 1.33 | 0.00 | 0.00 |
| DKK3 | ENSG00000050165 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PRG2 | ENSG00000186652 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.86 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MMP13 | ENSG00000137745 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 1.55 | 1.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 1.11 | 2.45 | 0.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.03 | 0.27 | 0.00 | 0.20 | 0.83 | 1.77 | 0.00 | 0.00 |
| PLBD1 | ENSG00000121316 | 0.00 | 0.51 | 0.21 | 1.46 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| LUM | ENSG00000139329 | 0.00 | 0.51 | 0.31 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 1.29 | 0.40 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.83 | 3.20 | 0.86 | 0.00 | 0.00 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 4.03 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| DCN | ENSG00000011465 | 1.11 | 0.51 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 1.66 | 0.52 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.83 | 0.75 | 1.29 | 0.00 | 0.00 | 0.00 | 0.56 | 0.41 | 0.00 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| EMILIN2 | ENSG00000132205 | 1.11 | 2.80 | 0.31 | 0.73 | 2.86 | 0.65 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.54 | 0.71 | 0.00 | 0.78 | 0.83 | 2.26 | 1.93 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 4.27 | 1.63 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| LAMA1 | ENSG00000101680 | 4.44 | 5.09 | 2.38 | 3.65 | 5.71 | 4.19 | 5.41 | 8.29 | 4.38 | 4.58 | 1.54 | 1.36 | 0.00 | 0.00 | 0.59 | 5.00 | 8.66 | 8.37 | 0.00 | 2.94 | 2.30 | 0.00 | 0.81 | 3.13 | 1.29 | 8.77 | 9.21 | 0.00 | 0.00 | 0.00 | 5.54 | 1.82 | 2.50 |
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