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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
cytochrome P450 family 4 subfamily F member 2	ENSG00000186115	CYP4F2	chr19:15878023-15898120:-	Tbio	169.482
NADPH dependent diflavin oxidoreductase 1	ENSG00000188566	NDOR1	chr9:137205670-137217009:+	Tbio	9.0873
cytochrome P450 family 2 subfamily J member 2	ENSG00000134716	CYP2J2	chr1:59893308-59926790:-	Tchem	127.897
geminin DNA replication inhibitor	ENSG00000112312	GMNN	chr6:24774931-24786099:+	Tbio	38.2259
PHD finger protein 12	ENSG00000109118	PHF12	chr17:28905250-28951771:-	Tbio	170.387
TATA-box binding protein associated factor, RNA polymerase I subunit A	ENSG00000143498	TAF1A	chr1:222557902-222589933:-	Tbio	81.9357
ATPase Na+/K+ transporting subunit beta 2	ENSG00000129244	ATP1B2	chr17:7646627-7657768:+	Tclin	16.6625
cathepsin A	ENSG00000064601	CTSA	chr20:45890144-45898820:+	Tchem	298.411
nuclear receptor subfamily 2 group F member 2	ENSG00000185551	NR2F2	chr15:96325938-96340263:+	Tbio	89.6844
folylpolyglutamate synthase	ENSG00000136877	FPGS	chr9:127794597-127814327:+	Tchem	197.515
Scm like with four mbt domains 2	ENSG00000198879	SFMBT2	chr10:7158624-7411486:-	Tdark	1.43869
carboxypeptidase A4	ENSG00000128510	CPA4	chr7:130293134-130324180:+	Tbio	21.2354
spondin 2	ENSG00000159674	SPON2	chr4:1166932-1208962:-	Tbio	20.6972
frizzled related protein	ENSG00000162998	FRZB	chr2:182833275-182867162:-	Tbio	272.421
contactin associated protein 2	ENSG00000174469	CNTNAP2	chr7:146116002-148420998:+	Tbio	160.837
glycoprotein M6A	ENSG00000150625	GPM6A	chr4:175632934-176002664:-	Tbio	45.9329
3-phosphoinositide dependent protein kinase 1	ENSG00000140992	PDPK1	chr16:2537964-2603188:+	Tchem	53.1135
solute carrier organic anion transporter family member 2A1	ENSG00000174640	SLCO2A1	chr3:133932696-134052184:-	Tbio	53.376
EPM2A glucan phosphatase, laforin	ENSG00000112425	EPM2A	chr6:145501583-145736024:-	Tbio	120.071
Wnt family member 10B	ENSG00000169884	WNT10B	chr12:48965340-48971763:-	Tbio	64.8026

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