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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
branched chain amino acid transaminase 1	ENSG00000060982	BCAT1	chr12:24810022-24949459:-	Tchem	38.331
E1A binding protein p300	ENSG00000100393	EP300	chr22:41091786-41180077:+	Tchem	3116.19
interleukin 24	ENSG00000162892	IL24	chr1:206897443-206904139:+	Tbio	276.579
solute carrier family 27 member 5	ENSG00000083807	SLC27A5	chr19:58479512-58512413:-	Tbio	186.227
fatty acid binding protein 4	ENSG00000170323	FABP4	chr8:81478419-81483263:-	Tchem	404.484
mannose binding lectin 2	ENSG00000165471	MBL2	chr10:52765380-52771700:-	Tbio	1667.73
calreticulin	ENSG00000179218	CALR	chr19:12938578-12944489:+	Tbio	894.333
carnitine palmitoyltransferase 1A	ENSG00000110090	CPT1A	chr11:68754620-68844410:-	Tchem	208.307
nectin cell adhesion molecule 4	ENSG00000143217	PVRL4	chr1:161070995-161089599:-	Tbio	75.836
ADAM metallopeptidase domain 17	ENSG00000151694	ADAM17	chr2:9488486-9555792:-	Tchem	889.893
glutathione S-transferase mu 2	ENSG00000213366	GSTM2	chr1:109668022-109709551:+	Tchem	138.427
trefoil factor 3	ENSG00000160180	TFF3	chr21:42311667-42315651:-	Tbio	311.491
inositol 1,4,5-trisphosphate receptor type 1	ENSG00000150995	ITPR1	chr3:4493348-4847840:+	Tchem	210.136
melanin concentrating hormone receptor 1	ENSG00000128285	MCHR1	chr22:40678750-40682814:+	Tchem	156.962
retinoic acid receptor beta	ENSG00000077092	RARB	chr3:25174332-25597932:+	Tclin	519.297
glycogen synthase kinase 3 beta	ENSG00000082701	GSK3B	chr3:119821323-120094417:-	Tclin	1876.17
fatty acid binding protein 7	ENSG00000164434	FABP7	chr6:122779475-122784074:+	Tbio	95.357
mitogen-activated protein kinase 14	ENSG00000112062	MAPK14	chr6:36027677-36111236:+	Tchem	4467.32
caspase 2	ENSG00000106144	CASP2	chr7:143288215-143307696:+	Tchem	296.878
RAS guanyl releasing protein 3	ENSG00000152689	RASGRP3	chr2:33436324-33564750:+	Tchem	24.1744

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