PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
endothelin 3ENSG00000124205EDN3chr20:59300427-59325992:+Tbio276.531
protein tyrosine phosphatase 4A1ENSG00000112245PTP4A1chr6:63521761-63583587:+Tchem55.1719
trinucleotide repeat containing 18ENSG00000182095TNRC18chr7:5306790-5425414:-Tdark0
TNF alpha induced protein 6ENSG00000123610TNFAIP6chr2:151357592-151380048:+Tbio124.939
CD22 moleculeENSG00000012124CD22chr19:35319261-35347355:+Tclin540.548
cytochrome P450 family 4 subfamily V member 2ENSG00000145476CYP4V2chr4:186191520-186213456:+Tbio807.358
hepatocyte nuclear factor 4 gammaENSG00000164749HNF4Gchr8:75407914-75566843:+Tbio9.75842
C-X-C motif chemokine receptor 3ENSG00000186810CXCR3chrX:71615916-71618517:-Tchem500.922
interleukin 2 receptor subunit betaENSG00000100385IL2RBchr22:37125838-37175054:-Tclin1163.57
acid phosphatase 3ENSG00000014257ACPPchr3:132317367-132368298:+Tchem893.037
CD4 moleculeENSG00000010610CD4chr12:6786858-6820808:+Tchem34698.4
tribbles pseudokinase 3ENSG00000101255TRIB3chr20:362835-397559:+Tbio151.077
norrin cystine knot growth factor NDPENSG00000124479NDPchrX:43948776-43973504:-Tbio276.18
polycystin 2, transient receptor potential cation channelENSG00000118762PKD2chr4:88007668-88077777:+Tbio535.885
CD59 molecule (CD59 blood group)ENSG00000085063CD59chr11:33698261-33736445:-Tbio17471.2
epiregulinENSG00000124882EREGchr4:74365143-74388751:+Tbio65.7608
CD163 moleculeENSG00000177575CD163chr12:7470813-7503893:-Tbio529.112
tet methylcytosine dioxygenase 2ENSG00000168769TET2chr4:105145875-105279816:+Tbio288.992
protein disulfide isomerase family A member 3ENSG00000167004PDIA3chr15:43746392-43773279:+Tbio212.8
dual specificity tyrosine phosphorylation regulated kinase 1AENSG00000157540DYRK1Achr21:37365790-37517450:+Tchem204.94

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