PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
gastric inhibitory polypeptideENSG00000159224GIPchr17:48958554-48968596:-Tchem839.154
phospholipase A2 group IIAENSG00000188257PLA2G2Achr1:19975431-19980416:-Tchem1041.29
lysyl oxidase like 1ENSG00000129038LOXL1chr15:73925989-73952137:+Tbio225.547
transforming growth factor beta receptor 1ENSG00000106799TGFBR1chr9:99104038-99154192:+Tchem479.941
smoothened, frizzled class receptorENSG00000128602SMOchr7:129188872-129213545:+Tclin331.285
protein tyrosine phosphatase 4A3ENSG00000184489PTP4A3chr8:141391993-141432454:+Tchem198.418
Y-box binding protein 1ENSG00000065978YBX1chr1:42682427-42702349:+Tbio399.934
lipocalin 2ENSG00000148346LCN2chr9:128149071-128153455:+Tbio1235.25
lipoprotein(a)ENSG00000198670LPAchr6:160531483-160664259:-Tbio2482.35
signal transducer and activator of transcription 6ENSG00000166888STAT6chr12:57095408-57132139:-Tchem401.459
matrix metallopeptidase 16ENSG00000156103MMP16chr8:88032009-88328025:-Tchem54.5498
N-acetyltransferase 2ENSG00000156006NAT2chr8:18391245-18401218:+Tbio1136.5
WNK lysine deficient protein kinase 1ENSG00000060237WNK1chr12:752593-911452:+Tbio333.315
apolipoprotein A1ENSG00000118137APOA1chr11:116835751-116837950:-Tbio4684.58
WW domain containing oxidoreductaseENSG00000186153WWOXchr16:78099413-79212667:+Tbio254.156
neurotrophic receptor tyrosine kinase 1ENSG00000198400NTRK1chr1:156815640-156881850:+Tclin875.589
ATP citrate lyaseENSG00000131473ACLYchr17:41866908-41930542:-Tchem190.28
potassium two pore domain channel subfamily K member 9ENSG00000169427KCNK9chr8:139600838-139703056:-Tclin151.598
fms related receptor tyrosine kinase 4ENSG00000037280FLT4chr5:180601506-180649624:-Tclin414.414
pappalysin 1ENSG00000182752PAPPAchr9:116153804-116402322:+Tbio1178.03

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