This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
1.82 (Driver)
Gscore (Del):
0.00
Recurrently amplified in 6 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
0.10
Recurrently mutated in 1 cancer type(s)
Overall
Tissue specific
Total fusion occurrence:
14 (Driver)
Fusions detected in 9 cancer type(s)
Overall
Tissue specific
CRISPR: COMMON ESSENTIAL
Functional class:
Kinase (protein kinase)
JensenLab PubMed score:
617.62 (Percentile rank: 92.40%)
PubTator score:
333.32 (Percentile rank: 90.53%)
Target development/druggability level:
TbioThese targets do not have known drug or small molecule activities that satisfy the activity thresholds detailed below AND satisfy one or more of the following criteria: 1) target is above the cutoff criteria for Tdark; 2) target is annotated with a Gene Ontology Molecular Function or Biological Process leaf term(s) with an Experimental Evidence code.
Tractability (small molecule):
Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
