PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
epoxide hydrolase 2ENSG00000120915EPHX2chr8:27490779-27545564:+Tchem390.772
Bruton tyrosine kinaseENSG00000010671BTKchrX:101349447-101390796:-Tclin758.085
lysine acetyltransferase 8ENSG00000103510KAT8chr16:31115754-31131393:+Tbio272.211
interleukin 16ENSG00000172349IL16chr15:81159575-81314058:+Tbio304.226
CD34 moleculeENSG00000174059CD34chr1:207880972-207911402:-Tbio10665.8
beta-2-microglobulinENSG00000166710B2Mchr15:44711477-44718877:+Tbio5675.92
AKT serine/threonine kinase 2ENSG00000105221AKT2chr19:40230317-40285536:-Tchem282.236
proopiomelanocortinENSG00000115138POMCchr2:25160853-25168903:-Tbio11417.6
hydroxysteroid 11-beta dehydrogenase 2ENSG00000176387HSD11B2chr16:67430652-67437553:+Tchem556.136
phosphogluconate dehydrogenaseENSG00000142657PGDchr1:10398592-10420144:+Tchem128.126
colony stimulating factor 2ENSG00000164400CSF2chr5:132073790-132076170:+Tbio8983.45
gonadotropin releasing hormone 1ENSG00000147437GNRH1chr8:25419260-25424654:-Tbio9261.62
protein arginine methyltransferase 5ENSG00000100462PRMT5chr14:22920511-22929585:-Tbio128.108
glutathione-disulfide reductaseENSG00000104687GSRchr8:30678061-30727926:-Tclin2185.12
elastinENSG00000049540ELNchr7:74027789-74069907:+Tbio4913.97
apolipoprotein A2ENSG00000158874APOA2chr1:161222292-161223631:-Tbio553.952
5-methyltetrahydrofolate-homocysteine methyltransferaseENSG00000116984MTRchr1:236795281-236903981:+Tbio153.485
interleukin 10ENSG00000136634IL10chr1:206767602-206772494:-Tbio8767.19
major histocompatibility complex, class II, DR beta 1ENSG00000196126HLA-DRB1chr6:32552990-32589848:-Tchem5085.8
cytochrome P450 family 27 subfamily B member 1ENSG00000111012CYP27B1chr12:57762334-57768986:-Tchem377.108

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