PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| mitochondrially encoded ATP synthase membrane subunit 8 | ENSG00000228253 | MT-ATP8 | chrM:8366-8572:+ | Tbio | 93.3111 |
| OTU deubiquitinase 5 | ENSG00000068308 | OTUD5 | chrX:48922028-48958386:- | Tbio | 7.08226 |
| taste 2 receptor member 31 | ENSG00000256436 | TAS2R31 | chr12:11030387-11031407:- | Tbio | 7.76667 |
| aspartyl aminopeptidase | ENSG00000123992 | DNPEP | chr2:219373546-219400022:- | Tchem | 9.85 |
| kelch repeat and BTB domain containing 12 | ENSG00000187715 | KBTBD12 | chr3:127915232-127987671:+ | Tdark | 0.111111 |
| FKBP prolyl isomerase 11 | ENSG00000134285 | FKBP11 | chr12:48921518-48926474:- | Tbio | 5.41429 |
| sterile alpha motif domain containing 1 | ENSG00000141858 | SAMD1 | chr19:14087840-14091036:- | Tdark | 1 |
| phosphatidylinositol-5-phosphate 4-kinase type 2 beta | ENSG00000276293 | PIP4K2B | chr17:38765689-38800126:- | Tchem | 15.6911 |
| serine/threonine kinase 40 | ENSG00000196182 | STK40 | chr1:36339624-36385896:- | Tbio | 9.66732 |
| major facilitator superfamily domain containing 8 | ENSG00000164073 | MFSD8 | chr4:127917805-127965995:- | Tbio | 20.7722 |
| kelch like family member 36 | ENSG00000135686 | KLHL36 | chr16:84648525-84667686:+ | Tdark | 0 |
| mercaptopyruvate sulfurtransferase | ENSG00000128309 | MPST | chr22:37019635-37029822:+ | Tbio | 34.1504 |
| ferric chelate reductase 1 | ENSG00000156869 | FRRS1 | chr1:99708703-99766631:- | Tdark | 2.30952 |
| G protein-coupled receptor 62 | ENSG00000180929 | GPR62 | chr3:51955314-51957504:+ | Tdark | 0.535714 |
| solute carrier family 8 member B1 | ENSG00000089060 | SLC8B1 | chr12:113298759-113359493:- | Tbio | 20.5278 |
| phosphorylase kinase catalytic subunit gamma 2 | ENSG00000156873 | PHKG2 | chr16:30748270-30761176:+ | Tchem | 14.5649 |
| cytochrome P450 family 2 subfamily A member 7 | ENSG00000198077 | CYP2A7 | chr19:40875439-40882752:- | Tbio | 21.1949 |
| adhesion G protein-coupled receptor A3 | ENSG00000152990 | ADGRA3 | chr4:22345071-22516054:- | Tbio | 8.04777 |
| dehydrogenase/reductase 1 | ENSG00000157379 | DHRS1 | chr14:24290598-24299833:- | Tdark | 1.61111 |
| poly(ADP-ribose) polymerase family member 6 | ENSG00000137817 | PARP6 | chr15:72241181-72272999:- | Tchem | 29.3667 |
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