PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
CD320 moleculeENSG00000167775CD320chr19:8302127-8308356:-Tbio24.8817
EGF like, fibronectin type III and laminin G domainsENSG00000164318EGFLAMchr5:38258409-38465021:+Tbio8.96944
abhydrolase domain containing 12, lysophospholipaseENSG00000100997ABHD12chr20:25294743-25390983:-Tchem10.9989
neuropeptide FF receptor 2ENSG00000056291NPFFR2chr4:72031804-72148067:+Tchem31.3137
aquaporin 2ENSG00000167580AQP2chr12:49950741-49958881:+Tbio453.964
endonuclease domain containing 1ENSG00000149218ENDOD1chr11:95089810-95132645:+Tdark0.433333
protein kinase AMP-activated non-catalytic subunit beta 1ENSG00000111725PRKAB1chr12:119667753-119681630:+Tbio40.0477
cholinergic receptor nicotinic epsilon subunitENSG00000108556CHRNEchr17:4897774-4903074:-Tclin67.8956
solute carrier family 35 member D2ENSG00000130958SLC35D2chr9:96320706-96383710:-Tbio8.37897
FKBP prolyl isomerase 2ENSG00000173486FKBP2chr11:64241003-64244132:+Tbio25.5436
solute carrier family 35 member D1ENSG00000116704SLC35D1chr1:66999332-67054099:-Tbio7.45202
solute carrier family 43 member 2ENSG00000167703SLC43A2chr17:1569267-1628886:-Tbio12.4048
aarF domain containing kinase 2ENSG00000133597ADCK2chr7:140673153-140696261:+Tbio1.14286
arylsulfatase DENSG00000006756ARSDchrX:2903970-2929351:-Tbio52.15
cystatin DENSG00000170367CST5chr20:23875935-23879750:-Tbio19.5927
tubulin beta 3 class IIIENSG00000198211TUBB3chr16:89919165-89936092:+Tclin421.45
tensin 2ENSG00000111077TNS2chr12:53046969-53064372:+Tbio18.3722
protein tyrosine phosphatase non-receptor type 9ENSG00000169410PTPN9chr15:75463251-75579289:-Tchem24.9363
guanosine monophosphate reductase 2ENSG00000100938GMPR2chr14:24232422-24239242:+Tbio3.43333
calpain 13ENSG00000162949CAPN13chr2:30722771-30820542:-Tdark3.80952

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