This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]
Overall distribution
Tissue specific distribution
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Overall distribution
Tissue specific distribution
Gscore (Amp):
Gscore (Del):
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Overall distribution
Tissue specific distribution
Mscore:
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Overall
Tissue specific
Total fusion occurrence:
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Overall
Tissue specific
Functional class:
Not specified
JensenLab PubMed score:
87.89 (Percentile rank: 70.77%)
PubTator score:
421.45 (Percentile rank: 92.27%)
Target development/druggability level:
TclinThese targets have activities in DrugCentral (ie. approved drugs) with known mechanism of action.
Tractability (small molecule):
Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
Tractability (antibody):
Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
