PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ATP binding cassette subfamily C member 1ENSG00000103222ABCC1chr16:15949577-16143074:+Tchem1539.98
monoamine oxidase AENSG00000189221MAOAchrX:43654907-43746824:+Tclin1692.71
C-C motif chemokine ligand 2ENSG00000108691CCL2chr17:34255218-34257203:+Tchem4030.37
SET domain containing 2, histone lysine methyltransferaseENSG00000181555SETD2chr3:47016429-47163967:-Tchem235.616
collagen type XI alpha 1 chainENSG00000060718COL11A1chr1:102876467-103108496:-Tbio97.2929
dopa decarboxylaseENSG00000132437DDCchr7:50458436-50565457:-Tclin620.383
interleukin 6 receptorENSG00000160712IL6Rchr1:154405193-154469450:+Tclin675.738
C-X-C motif chemokine ligand 12ENSG00000107562CXCL12chr10:44370165-44386493:-Tbio1837.87
laminin subunit gamma 2ENSG00000058085LAMC2chr1:183186238-183244900:+Tbio92.4337
CEA cell adhesion molecule 5ENSG00000105388CEACAM5chr19:41576273-41729798:+Tbio278.158
mesencephalic astrocyte derived neurotrophic factorENSG00000145050MANFchr3:51385047-51389397:+Tbio149.597
large tumor suppressor kinase 2ENSG00000150457LATS2chr13:20973032-21061547:-Tchem73.1769
kallikrein related peptidase 3ENSG00000142515KLK3chr19:50854915-50860764:+Tchem239.828
CASP8 and FADD like apoptosis regulatorENSG00000003402CFLARchr2:201116104-201176687:+Tbio1983.88
leptin receptorENSG00000116678LEPRchr1:65420652-65641559:+Tclin736.448
fatty acid binding protein 5ENSG00000164687FABP5chr8:81280363-81284777:+Tchem87.9708
EWS RNA binding protein 1ENSG00000182944EWSR1chr22:29268009-29300525:+Tbio476.747
lysine demethylase 8ENSG00000155666KDM8chr16:27203495-27221768:+Tbio12.8088
lysine demethylase 2AENSG00000173120KDM2Achr11:67119269-67258087:+Tchem35.5736
apelinENSG00000171388APLNchrX:129645259-129654937:-Tchem305.74

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