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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
caspase 3	ENSG00000164305	CASP3	chr4:184627696-184649509:-	Tchem	9598.33
Pim-2 proto-oncogene, serine/threonine kinase	ENSG00000102096	PIM2	chrX:48913182-48919024:-	Tchem	118.807
mevalonate diphosphate decarboxylase	ENSG00000167508	MVD	chr16:88651935-88663161:-	Tchem	213.615
NLR family pyrin domain containing 3	ENSG00000162711	NLRP3	chr1:247416156-247449108:+	Tchem	1402.63
maternal embryonic leucine zipper kinase	ENSG00000165304	MELK	chr9:36572862-36677683:+	Tchem	54.9737
prostaglandin E receptor 4	ENSG00000171522	PTGER4	chr5:40679498-40693735:+	Tclin	393.036
baculoviral IAP repeat containing 3	ENSG00000023445	BIRC3	chr11:102317450-102339403:+	Tchem	325.12
ryanodine receptor 2	ENSG00000198626	RYR2	chr1:237042205-237833988:+	Tclin	742.855
cartilage oligomeric matrix protein	ENSG00000105664	COMP	chr19:18782773-18791314:-	Tbio	414.199
gastrin releasing peptide	ENSG00000134443	GRP	chr18:59220168-59230774:+	Tbio	1520.12
hyaluronan mediated motility receptor	ENSG00000072571	HMMR	chr5:163460203-163491945:+	Tbio	154.87
CD40 ligand	ENSG00000102245	CD40LG	chrX:136648193-136660390:+	Tbio	1380.32
dickkopf WNT signaling pathway inhibitor 1	ENSG00000107984	DKK1	chr10:52314296-52318042:+	Tchem	570.568
complement C3b/C4b receptor 1 (Knops blood group)	ENSG00000203710	CR1	chr1:207496147-207640647:+	Tbio	1220.04
proteasome 20S subunit beta 4	ENSG00000159377	PSMB4	chr1:151399534-151401944:+	Tbio	13.9083
endothelin receptor type B	ENSG00000136160	EDNRB	chr13:77895481-77919768:-	Tclin	600.151
lysophosphatidic acid receptor 1	ENSG00000198121	LPAR1	chr9:110873263-111038458:-	Tchem	153.326
adrenoceptor beta 2	ENSG00000169252	ADRB2	chr5:148825245-148828687:+	Tclin	2620.8
DNA topoisomerase I	ENSG00000198900	TOP1	chr20:41028818-41124487:+	Tclin	487.834
ATP binding cassette subfamily B member 6 (Langereis blood group)	ENSG00000115657	ABCB6	chr2:219209768-219218990:-	Tbio	671.939

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