PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
RB transcriptional corepressor 1ENSG00000139687RB1chr13:48303751-48481986:+Tchem3208.82
melanoma cell adhesion moleculeENSG00000076706MCAMchr11:119308529-119321521:-Tbio408.119
macrophage stimulating 1ENSG00000173531MST1chr3:49683947-49689501:-Tbio201.04
insulin like growth factor binding protein 1ENSG00000146678IGFBP1chr7:45888357-45893668:+Tchem1034.64
CD3e moleculeENSG00000198851CD3Echr11:118304545-118316175:+Tclin193.689
protein kinase, DNA-activated, catalytic subunitENSG00000253729PRKDCchr8:47773108-47960183:-Tchem928.468
N-acetyltransferase 1ENSG00000171428NAT1chr8:18170477-18223689:+Tchem363.1
epoxide hydrolase 1ENSG00000143819EPHX1chr1:225810092-225845563:+Tchem435.99
C-X-C motif chemokine ligand 10ENSG00000169245CXCL10chr4:76021117-76023497:-Tbio1180.17
lactate dehydrogenase AENSG00000134333LDHAchr11:18394388-18408425:+Tchem280.454
C-X-C motif chemokine ligand 9ENSG00000138755CXCL9chr4:76001275-76007488:-Tbio395.095
tissue factor pathway inhibitor 2ENSG00000105825TFPI2chr7:93885397-93890991:-Tbio288.057
coagulation factor VIIIENSG00000185010F8chrX:154835788-155026940:-Tbio3069.55
BCL2 associated X, apoptosis regulatorENSG00000087088BAXchr19:48954815-48961798:+Tchem4544.85
solute carrier family 1 member 5ENSG00000105281SLC1A5chr19:46774883-46788594:-Tbio168.093
endothelial PAS domain protein 1ENSG00000116016EPAS1chr2:46293667-46386703:+Tchem520.4
carboxypeptidase MENSG00000135678CPMchr12:68842197-68971570:-Tchem61.5
calcitonin related polypeptide alphaENSG00000110680CALCAchr11:14966668-14972354:-Tchem1911.59
spleen associated tyrosine kinaseENSG00000165025SYKchr9:90801787-90898549:+Tchem863.61
nitric oxide synthase 2ENSG00000007171NOS2chr17:27756766-27800499:-Tchem5437.9

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