The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Overall distribution
Tissue specific distribution
Overall distribution
Tissue specific distribution
Gscore (Amp):
0.00
Gscore (Del):
3.85 (Driver)
Recurrently deleted in 13 cancer type(s)
Overall distribution
Tissue specific distribution
Mscore:
1.97 (Driver)
Recurrently mutated in 12 cancer type(s)
Overall
Tissue specific
Total fusion occurrence:
19 (Driver)
Fusions detected in 8 cancer type(s)
Overall
Tissue specific
Functional class:
Not specified
JensenLab PubMed score:
1137.42 (Percentile rank: 95.94%)
PubTator score:
3208.82 (Percentile rank: 99.04%)
Target development/druggability level:
TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
Tractability (small molecule):
Discovery PrecedenceTargets with ligands; Targets with crystal structures with ligands
