PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
solute carrier family 24 member 4ENSG00000140090SLC24A4chr14:92322581-92501483:+Tbio12.8872
protein tyrosine phosphatase 4A2ENSG00000184007PTP4A2chr1:31906421-31944856:-Tchem93.7487
cytochrome P450 family 2 subfamily U member 1ENSG00000155016CYP2U1chr4:107931369-107953457:+Tbio17.8257
two pore segment channel 2ENSG00000162341TPCN2chr11:69048897-69090604:+Tbio33.4966
transmembrane phosphatase with tensin homologyENSG00000274391TPTEchr21:10521553-10606140:+Tbio36.7478
acyloxyacyl hydrolaseENSG00000136250AOAHchr7:36512949-36724549:-Tbio21.5361
collagen like tail subunit of asymmetric acetylcholinesteraseENSG00000206561COLQchr3:15450133-15521751:-Tbio94.8619
suppressor of variegation 3-9 homolog 1ENSG00000101945SUV39H1chrX:48695554-48709012:+Tchem123.547
neuroligin 2ENSG00000169992NLGN2chr17:7404874-7419860:+Tbio20.8889
solute carrier family 1 member 6ENSG00000105143SLC1A6chr19:14950034-15022990:-Tbio42.3801
V-set and immunoglobulin domain containing 4ENSG00000155659VSIG4chrX:66021738-66040125:-Tbio25.2322
dual specificity tyrosine phosphorylation regulated kinase 2ENSG00000127334DYRK2chr12:67648338-67665406:+Tchem27.9147
apoptosis inducing factor mitochondria associated 3ENSG00000183773AIFM3chr22:20965108-20981360:+Tbio2.90476
gamma-glutamyl carboxylaseENSG00000115486GGCXchr2:85544723-85561547:-Tclin108.983
WAP four-disulfide core domain 3ENSG00000124116WFDC3chr20:45747944-45791932:-Tdark0.20202
potassium voltage-gated channel subfamily A member regulatory beta subunit 1ENSG00000169282KCNAB1chr3:156037701-156539138:+Tbio33.3479
glycoprotein hormones, alpha polypeptideENSG00000135346CGAchr6:87085498-87095406:-Tbio245.427
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1ENSG00000127578WFIKKN1chr16:629239-634116:+Tbio8.46097
prolyl endopeptidase likeENSG00000138078PREPLchr2:44316281-44361862:-Tbio17.3667
kelch like family member 22ENSG00000099910KLHL22chr22:20441519-20495883:-Tbio2.40833

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