PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
testis associated actin remodelling kinase 2ENSG00000070759TESK2chr1:45343883-45491166:-Tdark1.56667
oxoeicosanoid receptor 1ENSG00000162881OXER1chr2:42762481-42764261:-Tchem5.28333
potassium voltage-gated channel subfamily C member 4ENSG00000116396KCNC4chr1:110211343-110283100:+Tclin37.6833
meprin A subunit alphaENSG00000112818MEP1Achr6:46793390-46839782:+Tbio29.0762
solute carrier family 36 member 4ENSG00000180773SLC36A4chr11:93144171-93197964:-Tbio4.85952
rhomboid like 1ENSG00000103269RHBDL1chr16:675666-678268:+Tdark8.33333
synaptojanin 2ENSG00000078269SYNJ2chr6:157981887-158099176:+Tbio15.3401
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1ENSG00000103657HERC1chr15:63608618-63833942:-Tbio21.2664
solute carrier family 25 member 48ENSG00000145832SLC25A48chr5:135834649-135888637:+Tdark0.058824
sigma non-opioid intracellular receptor 1ENSG00000147955SIGMAR1chr9:34634722-34637809:-Tclin84.16
solute carrier family 9 member A2ENSG00000115616SLC9A2chr2:102619707-102711318:+Tbio45.88
G protein-coupled receptor kinase 6ENSG00000198055GRK6chr5:177403204-177442901:+Tbio54.6575
lysine demethylase 1BENSG00000165097KDM1Bchr6:18155329-18223853:+Tbio17.6111
TAFA chemokine like family member 3ENSG00000184599FAM19A3chr1:112720419-112727235:+Tdark0.6
Wnt family member 16ENSG00000002745WNT16chr7:121325367-121341104:+Tbio28.5397
ST3 beta-galactoside alpha-2,3-sialyltransferase 1ENSG00000008513ST3GAL1chr8:133454848-133571940:-Tchem46.6785
solute carrier family 7 member 14ENSG00000013293SLC7A14chr3:170459584-170586074:-Tdark2.96978
prostaglandin F2 receptor inhibitorENSG00000134247PTGFRNchr1:116910057-116990358:+Tbio13.4643
solute carrier family 39 member 3ENSG00000141873SLC39A3chr19:2732204-2740152:-Tbio11.3266
ethanolamine-phosphate phospho-lyaseENSG00000164089ETNPPLchr4:108742040-108763054:-Tdark3.64359

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