PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
cyclin dependent kinase like 5ENSG00000008086CDKL5chrX:18425583-18653629:+Tchem156.49
adenosine kinaseENSG00000156110ADKchr10:74151185-74709303:+Tchem225.861
quinoid dihydropteridine reductaseENSG00000151552QDPRchr4:17460261-17512234:-Tchem162.316
H3 clustered histone 2ENSG00000274267HIST1H3Bchr6:26031650-26032060:-0
interleukin 4ENSG00000113520IL4chr5:132673986-132682676:+Tbio6054.65
resistin like betaENSG00000163515RETNLBchr3:108743424-108757384:-Tbio33.7481
lysyl oxidase like 3ENSG00000115318LOXL3chr2:74532414-74555690:-Tbio21.5887
lamin B receptorENSG00000143815LBRchr1:225401502-225428925:-Tbio268.856
G protein-coupled receptor class C group 5 member BENSG00000167191GPRC5Bchr16:19856691-19886167:-Tbio5.69762
calcium voltage-gated channel auxiliary subunit gamma 4ENSG00000075461CACNG4chr17:66964910-67033398:+Tbio0.509221
choline O-acetyltransferaseENSG00000070748CHATchr10:49609095-49665104:+Tchem193.517
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3ENSG00000196104SPOCK3chr4:166733384-167234796:-Tbio5.05278
NUAK family kinase 2ENSG00000163545NUAK2chr1:205302059-205321791:-Tchem37.9953
transmembrane serine protease 9ENSG00000178297TMPRSS9chr19:2389771-2426239:+Tbio3.95
fibrinogen C domain containing 1ENSG00000130720FIBCD1chr9:130902438-130939286:-Tbio5.83333
SAGA complex associated factor 29ENSG00000176476CCDC101chr16:28553915-28591790:+Tbio6.35952
carboxypeptidase N subunit 1ENSG00000120054CPN1chr10:100042193-100081877:-Tchem110.984
oligodendrocyte myelin glycoproteinENSG00000126861OMGchr17:31272013-31297539:-Tbio40.4139
bromodomain and WD repeat domain containing 1ENSG00000185658BRWD1chr21:39184176-39321559:-Tbio4.44444
hydroxycarboxylic acid receptor 2ENSG00000182782HCAR2chr12:122701293-122703343:-Tclin98.8976

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