PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| glial cell derived neurotrophic factor | ENSG00000168621 | GDNF | chr5:37812677-37839686:- | Tbio | 927.979 |
| myotubularin 1 | ENSG00000171100 | MTM1 | chrX:150568619-150673322:+ | Tbio | 153.261 |
| fibroblast growth factor 17 | ENSG00000158815 | FGF17 | chr8:22042398-22048809:+ | Tbio | 10.9724 |
| serine peptidase inhibitor Kazal type 8 (putative) | ENSG00000229453 | SPINK8 | chr3:48306842-48328341:- | Tdark | 0 |
| calcium voltage-gated channel auxiliary subunit alpha2delta 2 | ENSG00000007402 | CACNA2D2 | chr3:50362799-50504244:- | Tclin | 16.0477 |
| solute carrier family 25 member 28 | ENSG00000155287 | SLC25A28 | chr10:99610522-99620609:- | Tbio | 9.36111 |
| prostaglandin I2 receptor | ENSG00000160013 | PTGIR | chr19:46620468-46625118:- | Tclin | 99.4804 |
| fatty acid binding protein 3 | ENSG00000121769 | FABP3 | chr1:31365625-31376850:- | Tchem | 401.672 |
| src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | ENSG00000125508 | SRMS | chr20:63540810-63547504:- | Tchem | 2.83333 |
| adenylate cyclase 8 | ENSG00000155897 | ADCY8 | chr8:130780301-131042426:- | Tbio | 58.8877 |
| chordin | ENSG00000090539 | CHRD | chr3:184380073-184390736:+ | Tbio | 56.5721 |
| aldehyde dehydrogenase 5 family member A1 | ENSG00000112294 | ALDH5A1 | chr6:24494852-24537207:+ | Tclin | 121.375 |
| calcium/calmodulin dependent protein kinase kinase 2 | ENSG00000110931 | CAMKK2 | chr12:121237691-121298308:- | Tchem | 80.5814 |
| cytotoxic and regulatory T cell molecule | ENSG00000109943 | CRTAM | chr11:122838500-122872639:+ | Tbio | 16.8679 |
| leucine rich repeat and Ig domain containing 2 | ENSG00000174482 | LINGO2 | chr9:27948078-28670286:- | Tbio | 9.99749 |
| C-C motif chemokine receptor 10 | ENSG00000184451 | CCR10 | chr17:42678889-42683917:- | Tbio | 49.9896 |
| butyrophilin subfamily 3 member A1 | ENSG00000026950 | BTN3A1 | chr6:26402237-26415216:+ | Tbio | 18.519 |
| thrombospondin 4 | ENSG00000113296 | THBS4 | chr5:79991311-80083287:+ | Tbio | 49.5133 |
| ribosomal protein S6 kinase A3 | ENSG00000177189 | RPS6KA3 | chrX:20149911-20267100:- | Tchem | 163.259 |
| phosphodiesterase 7A | ENSG00000205268 | PDE7A | chr8:65717510-65842322:- | Tclin | 65.3408 |
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