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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
collagen type VII alpha 1 chain	ENSG00000114270	COL7A1	chr3:48564073-48595267:-	Tbio	379.695
pyruvate kinase L/R	ENSG00000143627	PKLR	chr1:155289839-155301434:-	Tbio	237.649
keratin 19	ENSG00000171345	KRT19	chr17:41523617-41528308:-	Tbio	1381.44
FAT atypical cadherin 1	ENSG00000083857	FAT1	chr4:186587783-186726722:-	Tbio	188.712
SP110 nuclear body protein	ENSG00000135899	SP110	chr2:230167293-230225729:-	Tbio	96.9569
nuclear receptor subfamily 5 group A member 2	ENSG00000116833	NR5A2	chr1:200027602-200177424:+	Tchem	230.018
dihydrofolate reductase	ENSG00000228716	DHFR	chr5:80626228-80654983:-	Tclin	1580.07
inhibitor of nuclear factor kappa B kinase subunit beta	ENSG00000104365	IKBKB	chr8:42271302-42332653:+	Tchem	491.734
phospholipase D1	ENSG00000075651	PLD1	chr3:171600405-171810950:-	Tchem	185.889
solute carrier family 7 member 11	ENSG00000151012	SLC7A11	chr4:138164097-138242349:-	Tchem	185.58
CD1a molecule	ENSG00000158477	CD1A	chr1:158254137-158258269:+	Tbio	1104.14
LYN proto-oncogene, Src family tyrosine kinase	ENSG00000254087	LYN	chr8:55879813-56014168:+	Tclin	437.411
progesterone receptor	ENSG00000082175	PGR	chr11:101029624-101130524:-	Tclin	5388.46
dual specificity phosphatase 4	ENSG00000120875	DUSP4	chr8:29333064-29350668:-	Tbio	60.2545
S100 calcium binding protein A7	ENSG00000143556	S100A7	chr1:153457744-153460701:-	Tbio	147.789
cytochrome P450 family 2 subfamily E member 1	ENSG00000130649	CYP2E1	chr10:133520406-133561220:+	Tbio	1508.79
squalene epoxidase	ENSG00000104549	SQLE	chr8:124998497-125022283:+	Tchem	30.893
Wnt family member 3A	ENSG00000154342	WNT3A	chr1:228007051-228061260:+	Tchem	287.178
leucine rich repeat containing G protein-coupled receptor 5	ENSG00000139292	LGR5	chr12:71439770-71586310:+	Tbio	207.106
CD70 molecule	ENSG00000125726	CD70	chr19:6583183-6604103:-	Tbio	146.893

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