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IKBKB  
    


    
      Official symbol:  IKBKB
      Full name:  inhibitor of nuclear factor kappa B kinase subunit beta
      Location:  8p11.21
      Also known as:  IKK2, NFKBIKB, IKKB, IKK-beta
      Entrez ID:  3551
      Ensembl ID:  ENSG00000104365
      Summary:  The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

    

    
  Overall distribution
    
  Tissue specific distribution
    
 
  
 
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Gscore (Amp):  0.85  (Driver)
Gscore (Del):  0.00  
 
Recurrently amplified in 3 cancer type(s)
   

    
  Overall distribution
    
  Tissue specific distribution
    
 
Mscore:  0.00  
 
   

    
  Overall
    
  Tissue specific
    
 
Total fusion occurrence:  11  
 
Fusions detected in 5 cancer type(s)
 
 

    
  Overall
    
  Tissue specific
    
   CRISPR: STRONGLY SELECTIVE 
 RNAi: STRONGLY SELECTIVE 
   
   

    
      Functional class:  Kinase (protein kinase)
      JensenLab PubMed score:  790.14  (Percentile rank: 94.09%)
      PubTator score:  491.73  (Percentile rank: 93.21%)
      Target development/druggability level:  TchemThese targets have activities in ChEMBL or DrugCentral that satisfy the activity thresholds detailed below.
      Tractability (small molecule):  Clinical PrecedenceTargets with drugs in phase II or above; Pre-clinical targets
      Tractability (antibody):  

    







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