PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
cadherin EGF LAG seven-pass G-type receptor 1ENSG00000075275CELSR1chr22:46360834-46537170:-Tbio25.4107
UDP-glucose ceramide glucosyltransferaseENSG00000148154UGCGchr9:111896766-111935369:+Tclin214.231
glutamate dehydrogenase 1ENSG00000148672GLUD1chr10:87050486-87094866:-Tbio413.814
integrin subunit alpha 11ENSG00000137809ITGA11chr15:68296533-68432162:-Tbio15.3341
hypoxia inducible lipid droplet associatedENSG00000135245HILPDAchr7:128455849-128458418:+Tbio13.9775
solute carrier family 7 member 4ENSG00000099960SLC7A4chr22:21028718-21032840:-Tbio26.9809
vitrinENSG00000205221VITchr2:36696690-36814792:+Tbio411.207
DNA polymerase betaENSG00000070501POLBchr8:42338454-42371808:+Tchem804.131
protein kinase AMP-activated non-catalytic subunit beta 2ENSG00000131791PRKAB2chr1:147155106-147172550:-Tbio5.32635
survival of motor neuron 1, telomericENSG00000172062SMN1chr5:70925030-70953942:+0
tankyrase 2ENSG00000107854TNKS2chr10:91798312-91865276:+Tchem407.84
integrin subunit alpha 8ENSG00000077943ITGA8chr10:15513949-15720125:-Tbio17.0479
solute carrier family 45 member 1ENSG00000162426SLC45A1chr1:8317826-8344167:+Tdark236.21
solute carrier family 17 member 5ENSG00000119899SLC17A5chr6:73593379-73654155:-Tbio3906.63
cochlinENSG00000100473COCHchr14:30874514-30895065:+Tbio142.743
flavin containing dimethylaniline monoxygenase 4ENSG00000076258FMO4chr1:171314208-171342084:+Tbio9.13611
prokineticin 2ENSG00000163421PROK2chr3:71771656-71785206:-Tbio146.978
pseudopodium enriched atypical kinase 1ENSG00000173517PEAK1chr15:77100656-77420144:-Tbio214.398
Rh family B glycoproteinENSG00000132677RHBGchr1:156369212-156385219:+Tbio28.2929
G protein-coupled receptor 37ENSG00000170775GPR37chr7:124745997-124765627:-Tbio33.0631

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